Peer Reviewed Studies

We have selected a variety of studies here. Many more can be found by searching PubMed.

Ozone therapy in veterinary medicine: A review

March 2020 | Italy

Ozone (O3) is a triatomic form of oxygen. As O3 rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O3/O2 is used in medicine. ATP is widely available for cellular activity. O3 can be administered via the systemic and local routes...

Comparative evaluation of the effect of Ozone therapy and Photodynamic therapy in non-surgical management of Chronic periodontitis

Oct 2020 | Italy

A split-mouth longitudinal study was conducted to compare and evaluate the effect of ozonated water and photodynamic therapy (PDT) in nonsurgical management of chronic periodontitis, along with mechanical debridement procedure...

Ozone therapy in COVID-19: A narrative review

October 2020 | Italy

The performance of horses undergoing regular intense exercise is adversely affected by oxidative stress. Thus, it is important to increase antioxidant production in horses in order to reduce oxidative stress. Ozonated autohemotherapy (OAHT) reportedly promotes antioxidant production...

Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro

October 2020 | Italy

In clinical practice, administration of low ozone (O3) dosages is a complementary therapy for many diseases, due to the capability of O3 to elicit an antioxidant response through the NuclearFactor Erythroid 2-Related Factor 2 (Nrf2)-dependent pathway...

Aqueous ozone therapy improves the standard treatment of leishmaniasis lesions in animals leading to local and systemic alterations.

October 2020 | Brazil

The current treatment of leishmaniasis presents some problems, such as cell toxicity, parenteral route, and time of treatment. Ozone emerges as an option to accelerate the standard treatment due to the immunomodulatory, antioxidant, and wound healing activity reported in the literature...

Efficacy of Intradiscal Ozone Therapy with or without Periforaminal Steroid Injection on Lumbar Disc Herniation: A Double-Blinded Controlled Study

March 2020 | Turkey

Intradiscal ozone therapy, a minimally invasive technique, is used in patients that do not respond to standard conservative therapies for low back pain due to degenerative disc-induced lumbar disc herniation (LDH). Many studies on clinical efficacy lack a standardized injection method and are limited by inadequate study design...

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

March 2020 | Turkey

We here present wide scientific background indicating how a natural bioactive molecule with antioxidant/anti-apoptotic and pro-autophagy properties such as the ozone (O3) can represent a potential new strategy to delay neurodegeneration...

Intrauterine therapy with ozone reduces subclinical endometritis and improves reproductive performance in postpartum dairy cows managed in pasture-based systems

September 2020 | Ecuador

New postpartum strategies have been developed in dairy cows to ameliorate uterine health and reproductive performance, especially the first service conception rates. This study aimed to assess the effect of intrauterine therapy with ozone (IUTO) in early postpartum...

Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis

June 2020 | Brazil

To verify the influence of ozone (O3) therapy on an experimental model of rheumatoid arthritis (RA), 30 male Wistar rats were randomly allocated to 2 groups, control (C) and treatment (T), and subdivided into control (C12, C48, C72) and treatment (T12, T48, T72) groups...

Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

April 2020 | Italy

Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity.

Ozone at low concentrations does not affect motility and proliferation of cancer cells in vitro

April 2020 | Italy

Exposure to low ozone concentrations is used in medicine as an adjuvant/complementary treatment for a variety of diseases. The therapeutic potential of low ozone concentrations relies on their capability to increase the nuclear translocation of the Nuclear factor erythroid 2-related factor

Ozonated oil in wound healing: what has already been proven?

March 2020 | Brazil

Acute or chronic inflammatory reactions aim to control lesions, resist to pathogens attack and repair damaged tissue. The therapeutic administration of ozone known as ozone therapy appears as a possible treatment for tissue repair, as it promotes the healing of wounds...

The efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury

March 2020 | Turkey

Comparison of low-level laser therapy (LLLT) and ozone therapy (OT) methods for the treatment of facial nerve injury (FNI) in rats, evaluated by histomorphometric measurement analysis...

Topical ozone therapy restores microbiome diversity in atopic dermatitis

March 2020 | China

Topical ozone therapy is highly effective for treatment for AD. It can change the proportional ratio of Staphylococcus and Acinetobacter, thereby restoring the microbiological diversity in AD lesions...

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy - Induced Toxicity: Review and Prospects

November 2019 | Spain

Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy to prevent and/or treat chemotherapy-induced toxicity, and how its effect is linked to a modification of free radicals and antioxidants...

Effects of ozonated autohemotherapy on the antioxidant capacity of Thoroughbred horses

January 2016 | Japan

The performance of horses undergoing regular intense exercise is adversely affected by oxidative stress. Thus, it is important to increase antioxidant production in horses in order to reduce oxidative stress. Ozonated autohemotherapy (OAHT) reportedly promotes antioxidant production...

The efficacy of intraarticular PRP, ozone and PRP + ozone injections in patients with osteoarthritis

December 2019 | Turkey

Osteoarthritis (OA) is a degenerative disease associated with the deterioration of the processes of production and destruction of cartilage and synovial tissues caused by various traumatic, biomechanical, inflammatory or genetic factors. This study aims to evaluate the severity of disease globally by intra-articular injection of ozone, ozone + PRP and PRP alone in patients with Knee OA...

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