After five decades characterized by empiricism and several pitfalls, some of the basic mechanisms of action of ozone in pulmonary toxicology and in medicine have been clarified. The present knowledge allows to understand the prolonged inhalation of ozone can be very deleterious first for the lungs and successively for the whole organism...

Prolozone is a technique that combines the principles of neural therapy, Prolotherapy and ozone therapy. It involves the injecting combinations of procaine, anti-inflammatory medications, homeopathics, vitamins, minerals, proliferatives and ozone/oxygen gas into degenerated or injured joints...

The potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological components. The line between effectiveness and toxicity of ozone may be dependent on the strength of the oxidative stress...

We hope that this document, which is primarily intended for health practitioners using ozone who want to refine their techniques and learn about the scientific bases that support the clinical use of this therapy, would be also useful to the health authorities as guideline and summary of the more recent research published worldwide...

Ozone therapy has been reported to be effective in humans, but there was still small numbers of reports in veterinary medicine. Rectal insufflations (RI) of oxygen-ozone was effective as well as major ozone autohemotherapy (AHT), the procedure was easy to perform, painless, inexpensive and had no side effects...