Something is just not right with your beloved pet. You dread the appointment you just made with your veterinarian and you pray that the news you hear will not include the big “C” word — Cancer.

These days, it seems most pets are being diagnosed with some sort of cancer, whether it be a rare or common form. But, does cancer have to result in euthanizing a beloved pet? Absolutely not! Ozone therapy is a little known treatment that can help your pet’s body attack cancer cells and restore his/her health.


Animals, like humans, are living longer than their ancestors, but living longer exposes animals to more diseases and other consequences of aging.

According to the Animal Cancer Foundation, there are an estimated 65 million dogs and 32 million cats in the United States. Of these, approximately 12 million are diagnosed with cancer each year.

An organization named FETCH a Cure published an article indicating that cancer is the leading cause of death in 47% of dogs and 32% of cats. Some of the more common types of cancer in pets include:


Mitochondria are tiny cellular structures that help create energy for cells. Although small, they make up 10% of an animal’s total body weight. Healthy mitochondria are crucial to the health of our pets. If you do a quick search on PubMed for “mitochondria” AND “oxygen” you’ll get 44,609 results. That’s because there is a direct link between mitochondrial health and oxygen utilization.

The formula goes like this:  Optimal Oxygen Utilization = Healthy Mitochondria = Healthy Pet

Dr. Otto Warburg, winner of the Nobel Prize for cancer research, said, “Cancer has only one prime cause. It is the replacement of normal oxygen respiration of the cells of the body by an anaerobic (i.e., oxygen-deficient) cell respiration.”

In essence, Dr. Warburg was saying that, if we can correct the breathing patterns of cells, we can eliminate cancer.


If you purchase a box of Kellogg’s Smart Startâ cereal, you will see “Original Antioxidants” printed in bold letters on the front. Everyone knows the importance of antioxidants, but we really have no clue as to why they are important. Antioxidants are important because they protect us and our pets from too much oxidation.

Picture a rusty nail. The rusting is the process of oxidation at work. Oxidation breaks down the steel that makes up the nail, and, if given enough time, oxidation will cause it to disintegrate completely. The same is true of cells. While they need oxygen to live, too much oxidation will ultimately destroy them. It’s a balancing act. Like a tightrope walker, your pet’s body must use oxygen efficiently without allowing it to overwhelm your beloved’s antioxidant defense system.

The antioxidant system is ultimately stimulated through the use of ozone therapy. A small, controlled dose of ozone applied to the body will produce an ideal amount of oxidative stress. This stress will produce antioxidant enzymes, which are critical to optimizing oxygen utilization.

That is what ozone therapy is all about–Optimizing Oxygen Utilization!

Oxygen is the single most important nutrient that animals need. In fact, Dr. Arthur Guyton who wrote The Textbook on Medical Physiology said, “All chronic pain, suffering and diseases are caused by a lack of oxygen at the cell level.”

 A pet with a disease ALWAYS has a decreased ability to utilize oxygen. If we can improve the ability of an animal’s body to utilize oxygen, better health will follow. It’s that simple.

“Whether they are being managed strictly with holistic care or concurrently with conventional care, my cancer patients’ quality of life is far superior to the average cancer patient….in fact I can’t think of one that hasn’t far exceeded their prognosis for length and quality of life.” – Dr. Judith Shoemaker


The IVC Journal published an article entitled Ozone Therapy for Cancer in Veterinary Medicine. The article explains that ozone contributes to the formation of healthy cells AND destroys unhealthy cells. This combination is the key to helping animals diagnosed with any type of cancer.

In her insightful book entitled Ozone Therapy in Veterinary Medicine, Dr. Zullyt Rodriguez reviews various studies that have successfully observed the effects of ozone therapy when it comes to cancer. In fact, an entire chapter is devoted to this subject and to understanding the mechanisms of action that may be involved.

The types of cancer discussed in the book include:

Major Autohemotherapy (MAHT), rectal insufflation, intratumor gas injections and intraperitoneal gas injections were the methods of ozone administration used in these studies.

Some of the effects that were observed as result of ozone therapy include:

Beyond what ozone therapy can do for cancer, a section of that chapter in Dr. Rodriguez’s book was also dedicated to showing how ozone therapy can be used as a complement treatment to radiation and chemotherapy. When animals undergo radiation and/or chemotherapy, they are prone to numerous side effects, which can lead to their deterioration.

The studies proved that ozone therapy can effectively lower inflammation, reduce long-term oxidative stress (this does not contradict what we mentioned earlier), protect the tissues and organs, increase appetite and improve quality of life of a cancer patient. In some cases, ozone therapy allowed traditional treatments to continue where negative side effects would have definitely put a halt to them.

That same chapter concludes with two tables that summarize the data contained in the chapter. Those tables are combined into one chart below.

Murine Tumors:
Ehrlich’s Ascites (TAE), Lung Tumor RL-67, L1210 Leukemia and L-P388 Leukemia
Rectal and intratumoral routes (6, 12 and 49 mg/L) Tumors were not reduced. Only lung metastasis decreased Rodriguez et al., 1998
Mice with TAE and Sarcoma-37 Rectal route, OOP (19, 26 and 42 mg/L) 1 ml per animal, 12 days Reduced the number of disseminated cells in the lung, dependent dose Menendez et al., 2008
Lewis Lung Carcinoma (Mice) OOP 4, 11, 20 and 35 mg/L,
i.p route, 15 applications
Significantly reduced tumor size of Lewis Lung carcinoma cells Menendez et al., 2008
Rabbits, VX2 Tumor, Head and Neck OOP (50 mg/ml of OOM 80 ml/kg volume of weight) intraperitoneally, during 5 days 50% survival and 85% had regression of the tumor with no metastasis. Increased leukocytes and prostacyclin Schultz et al., 2008
Schultz et al., 2012
Rabbits, VX2 Tumor, Head and Neck OOP (50 mg/ml of OOM 80 ml/kg volume of weight) intraperitoneally, during 5 days Regression of the tumor mass, associated with the increase of the CD3 white cells and its infiltration to the tumor tissue and COX-2 Rossman et al., 2014
Proctitis Induced by Irradiation in Rats Treatment with OOO, rectal 1 ml, during 10 days Reduced inflammation and histological changes Gultekin et al., 2013
Radiation Damage to Liver, Lung and Intestine in Rats OOP (60 mg/ml of OOM) vol. 2, 3 ml/ animal, for a 0,7 mg/kg dose intraperitoneally, during 5 days prior to the injury Reduced FNT, IL1 and AST and ALAT levels. Increased SOD activity and preserved tissue structure Bakkal et al., 2013 Gultekin et al., 2013
Damage to Methotrexate-Induced Ileum, Liver and Kidneys in Rats OOP at 0,72 mg/kg dose, applied intraperitoneally for 15 days Increased GSH content in renal tissue and reduced levels of proinflammatory cytokines Kesik et al., 2009
Aslaner et al., 2015
Kidney Damage by Cisplatin in Rats OOM treatment (10, 30 and 50 mg/L) applied rectally for 5 consecutive days Attenuated renal histological damage and restored levels of GSH, CAT, SOD and GPx depleted by CDDP Gonzalez et al., 2004
Kidney Damage by Cisplatin in Rats OOP applied rectally for 15 days in the model of CDDP-induced renal damage. OM at the same doses as the previous one Protected kidney tissue by restoring the enzymatic antioxidant system (SOD, CAT, GPx) of renal tissue, thus preserving both renal structure and function. Reduced Apoptosis Borrego et al., 2004
Borrego et al., 2006


When it comes to your beloved pet, ozone therapy could be the difference between life and death. We’ve had some pretty amazing testimonies, and here are just a few of them.

Cardiac Cancer

“We had a real miracle case and now ozone is something that we use in all of our cancer cases. One particular case that got us excited was a Golden Retriever that came in in respiratory distress. She received a diagnosis of cardiac cancer that had metastasized to the lungs and liver. It was recommended for the dog to just go home, get comfortable and then be euthanized when the fluid recurred in the next 7-10 days. She came in and we did ozone therapy (MAHT and mAHT) with UV. We did it daily for five days and then we did it twice the second week. We then had it ultra-sounded by a specialty ultrasound practitioner from Texas A&M. She could find no cancer. We’ve had it ultra-sounded and radiographed two more times. We’re now six months into this and completely cancer free.” – Dr. Dan Ahrens

Cancer Treatments at Home

“Woo hoo! I just did my first ozone treatments with my girls all by myself! I opened the front door, placed some pureed beef on the screen door glass and while each one was licking it off, in went the catheter, pushed the plunger on the syringe, held their tail down and all was happy! Treats after for all! I made it a celebration! Thank-you O3 vets for being so kind this morning and walking me through what I thought would be something I could never do! Ozone is for both of my girls who have cancer. It has made a tremendous difference in their lives!” – Julie Hoffman, Pet Parent


“I remember the first day we actually did the ozone here at the vet. She had so much energy when we left even that evening. The next day we could definitely see a difference because that was right after she’d been diagnosed, and we didn’t have her on a protocol of herbals or anything like that at the time.

We’re doing the subcutaneous when we come to the vet. We actually purchased a device that we can do at home, so we do it almost daily, and it’s a really quick treatment. Cierra tolerates it really, really well. We give her a treat while we’re administering the ozone, and she doesn’t mind it. We set an alarm pretty much every day. We both work from home so it’s easy, and we think it’s definitely helping. Now she can walk a half to a mile without any limping. She seems to have more energy. Her personality is pretty much the same. I would say she’s more playful than she’s been in a while.” – Laurie and Jan Hageman, Pet Parents

Cruciate Cases

“I see tons of cruciate cases here that I do either PRP or blood therapy. Since I incorporated ozone therapy, they heal 50% faster sometimes after the first treatment!!!! I inject the gas after the treatment, so I’m a true believer.” – Dr. Sasan Haghighat

Malignant Tumor in Thoracic Cavity

“Predominantly she has received ozone therapies, fecal transfers, and recently UV blood treatments. She has responded miraculously!! The blood ultraviolet treatments have, to date, provided the most significant improvement. Imperative to me at the onset was the fact Olivia have, at the very least, a good quality to every day I attempted to keep her alive. There have been a handful (three, maybe four) of days where it was clear she was not feeling well, did not want to eat, was having difficulty breathing. But those have been far and few between.” – Elizabeth E. Wallace, Pet Parent


 If your pet has cancer, the only obvious conclusion is to make sure they are receiving ozone therapy.

We recommend finding a veterinary ozone practitioner and getting started right away. Here’s a list of all the ozone veterinarians that we know of.

If you can’t find an ozone vet near you, there’s always the option to treat your pet on your own at home. If you choose to do this, we recommend that you have some sort of veterinary oversight.

We truly hope that you will benefit from the information in this article! And, we would love to hear from you. Please comment below or drop us an email at

If you would like more information about ozone therapy and cancer in animals than what this article contains, you can watch this video.




Sign up now for the full-day, Pre-Conference Veterinary Training – Medical Ozone and Biophotonic Therapy at SOPMed 2015, on Thursday, June 25, and get a $195 discount on the cost of the main Conference.

But this isn’t just a great deal, it’s also training you cannot afford to miss whether you are new to alternative photonic and oxidative therapies or need a top-notch refresher course. Everyone interested in integrative veterinary medicine will benefit from the in-depth session beginning with an overview of ozone and biophotonic therapy in a classroom setting and continuing in the wet labs with hands-on instruction using live animals. This intensive course will be taught by Dr. Kathy Backus and Jon Lowe and will run from 9:00 am until 5:00 pm.

Following the pre-Conference training, the main Conference on Friday and Saturday, June 26-27, offers a broad range of Lectures and General Sessions by renowned experts on subjects as diverse as medical lights and lasers, redox signaling and business success, to name just a few.

On Saturday veterinarians will spend the afternoon with four of the nation’s top alternative veterinarians discussing areas of special interest, including:

• Margo Roman, DVM – Ozone in Micro-Biome Restorative Therapy and Prolozone Therapy
• Betsy Hershey, DVM – O3UV in Oncology
• Kathy Backus, DVM – Pulsed Electro Magnetic Fields (PEMF)
• Rachel Jones, DVM – O3 Case Studies

And then there is the venue itself, Snowbird, Utah, one of the nation’s premiere skiing destinations is also a summertime haven for outdoor enthusiasts who enjoy activities like hiking, biking, horseback riding, and gondola rides through the breathtaking mountains and valleys. Others may want to treat themselves to a little R & R and pampering courtesy of the Cliff Lodge Spa where SOPMed attendees get a 50% discount on services and amenities including, a relaxing solarium, full-service salon, eucalyptus steam room, dry sauna, yoga room, rooftop lap pool, and an extensive fitness gym.

So take advantage of this great opportunity to get excellent training at an excellent price at SOPMed 2015 in Snowbird Utah, June 25 – 27, 2015. Contact us at for discount registration information and check out to learn more about the entire Conference. is a young and innovative company with the goal of helping alternative and integrative veterinarians understand and use oxidative therapies in their daily practices. One way to accomplish this is to begin a dialogue about these therapies, the science behind them, the practitioners that use them, and the outcomes that will serve to educate and enlighten veterinarians and pet owners alike.

That said…Welcome to the O3Vets blog!

It is our hope that this blog will be a venue for diverse information sharing, from answering equipment-related questions to interviews with integrative practitioners to news and upcoming events. While we will do our best to keep it fresh and informative, we also welcome your ideas, interests and suggestions at

But wait, there’s more!

In addition to this blog, we are also providing an online forum where practitioners can network, converse and give and get answers to their medical questions. We want you to feel free to make this forum your peer-to-peer place to go for intelligent, insightful and lively discussions about oxidative therapies and how they improve quality of care. Periodically, we will also contribute to the forum as needed or requested.

Another service we are working on is a newsletter, which will provide the means for further developing some of the issues and topics that come up in the blog and the forum, and others that require more space to address properly. Again, we are always open to your ideas and suggestions so do not hesitate to drop us a line at and let us know what’s on your mind.

And last but not least, we also would like to invite veterinarians that use ozone in their practices to take advantage of the O3Vets Practitioners map, which is on our web site and available to the public, worldwide. Simply go to, click on the “Practitioners” tab and fill out the brief form. That’s all it takes and as soon as possible we will “put your practice on the map.”

Thank you for stopping by. We look forward to learning, sharing and growing with you!

Ozone was discovered in 1785 by Dutch physicist Martinus Van Marum, who smelled a peculiar sent which was being made near electrostatic machines. It was later synthesized, and in 1857 the first Ozone insufflations were tested on animals and humans. Since then, it has spread all across the world for many different purposes. Ozone therapy has a long history and many scientific studies performed to back up its validity.

Russia has recognized ozone therapy on a state level for medical use as well as for dermatological purposes!  According to the Ministry of Public Health in Cuba, ozone therapy has been applied all throughout the country since 2009.

Altogether, there are over 26,000 ozone therapists throughout the world. With wide acceptance, many studies, and numerous practitioners, we have learned a great deal about how to use ozone.

There are a variety of ways in which ozone therapy can be administered to the patient. How do you know which one to use? In the following blog posts, I will be going over the different methods of applying ozone. In this one, however, I am going to be giving you an overview of all of them.

Major Autohemotherapy

Major autohaemotherapy calls for the 10-250 ml of the patient’s blood to be drawn out. Ozone is then injected into the blood and the ozonated blood is re-introduced into a vein. These methods have been used to treat a wide variety of health problems. It is probably the most commonly used method of administration for ozone therapy today.

Minor Autohemotherapy

Minor autohaemotherapy involves using a syringe to remove a small amount of the patient’s blood from a vein with a syringe. The blood is then treated with an equal amount of ozone and given back to the patient as an intramuscular or subcutaneous injection. The blood and ozone becomes a type of auto-vaccine, which can be very specific and effective.

Direct intra-arterial and intravenous application (DIV)

An ozone/oxygen mixture is slowly injected into an artery or vein with a hypodermic syringe. Though not recommended by many within the ozone therapy world due to the danger of creating an embolism, this method is used primarily for arterial circulatory disorders.


Ozone is applied through the rectum and absorbed into the body through the intestine. Used for a wide variety of health problems, this method is considered one of the safest.

Ozonated water

This method calls for ozone gas to be bubbled through distilled water or saline.  The water is used externally to bathe wounds, burns and slow-healing skin infections.

Intra-articular injection (prolozone)

In this method, a specific mixture of procaine, vitamins, minerals and homeopathic remedies are injected directly into the joints. Ozone is also injected to the same site. It is used primarily by physicians throughout the world to treat joint pain, herniated discs, arthritis, and other joint diseases.

Intramammary infusion 

Instead of antibiotics, this can be very effective for mastitis in large animals.  The lack of side effects or residue in animals such as dairy cows makes it a perfect choice as it will not affect the quality of their milk as an antibiotic would.  

Limb bagging

This non-invasive method uses a specially made plastic bag that is placed around the area to be treated. Ozone is pumped into the bag and absorbed into the body through the skin.

Ozonated oil

Used primarily to treat skin problems, ozone gas is added to olive, hemp, sunflower or other oils and applied as a balm or salve for long term, low-dose exposure. Studies show a more rapid healing effect. 

Inhalation of ozone

Ozone can be bubbled through olive oil and the resulting atomized oil/ozone mix can be safely inhaled

You’ll want to watch out for our next blog which will be going over the differences between major and minor autohemotherapy.